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非天然氨基酸及其它砌块合成
醋酸普兰林肽
名称
醋酸普兰林肽
分子结构式
CAS号
196078-30-5
分子式
C171H269N51O53S2
分子量
3951
作用靶点
Amylin Receptor
序列号
H-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Pro-Ile-Leu-Pro-Pro-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2
短序列号
KCNTATCATQRLANFLVHSSNNFGPILPPTNVGSNTY
国际标识符代码
NRKVKVQDUCJPIZ-MKAGXXMWSA-N
纯度
95%
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Pramlintide Acetate is the acetate salt form of pramlintide, a peptide analogue of human amylin with 3 proline substitutions at position 25, 28 and 29, with antihyperglycemic activity. By mimicking amylin, pramlintide slows gastric emptying, inhibits digestive secretions (gastric acid, pancreatic enzymes, and bile), reduces glucagon secretion, and increases satiety; all of these actions are mediated mostly by glucose-sensitive areas in the brain stem. The overall result is a decrease in blood glucose levels. The use of pramlintide may cause an increased risk of insulin-induced hypoglycemia.